Study of colchicine analysis method - Database & Sql Blog Articles

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Study on Analytical Method of Colchicine

Product Name: colchicine

English: Colchicine

Alias: colchicine, 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one, N-(5,6,7,9-tetrahydro- 1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-acetamide

Source of extraction: bulbs and leaves of the genus Colchicum autumnale L., Iphigenia indica Kunth et Benth, etc.

Properties: light yellow crystal or crystalline powder, taste, bitter taste, see photochromism. Mp 157 ° C (ethyl acetate recrystallization), specific optical rotation [α] 17D-429 ° (1.72%, water), -121 ° (0.9%, chloroform), the maximum absorption wavelength in ethanol is 243 nm and 350.5 nm. This product is easily soluble in water, ethanol and chloroform, soluble in benzene, insoluble in petroleum ether, 0.5% of this product is weakly acidic. LD50 (mouse, abdominal cavity) 6.1 mg/kg. pK (20 ° C) = 12.35, pH 5.9. Since the nitrogen atom is an amide structure in the side chain, it is not alkaline.

Production method: This product is an alkaloid extracted from the bulb of Liliaceae plant Lijiangshan mushroom. The mushroom powder was extracted with 85% ethanol and refluxed for 4 hours. The obtained ethanol solution was concentrated to a semi-gel, and diluted with distilled water. The filtrate was acidified with 10% sulfuric acid, extracted with chloroform, and then concentrated. The crude colchicine obtained by crystallization is recrystallized to obtain a finished product. The total yield of the raw medicine Shanshan mushroom powder was 0.15%. Most of the foreign countries are extracted from the bulbs of the genus colchicum colchicum.

The role of colchicine: anti-gout drugs, anti-tumor drugs. For the typical inhibition of cell mitosis, cell mitosis stops in the M phase. It has a significant effect on breast cancer and can also be used in cervical cancer, esophageal cancer, lung cancer, gastric cancer and chronic myeloid leukemia. It can also be used for acute episodes of gout, with anti-inflammatory and analgesic effects. The preparations are tablets and injections. In recent years, its clinical application has been further expanded, mainly: prevention of atherosclerosis; treatment of cirrhosis; treatment of periodic fever caused by abnormal catecholamines; treatment of Behcet's disease; treatment of lumbar disc herniation; intractable low back pain and sciatica; Adhesion; refractory idiopathic thrombocytopenic purpura; persistent inflammatory erythema; advanced schistosomiasis; idiopathic pulmonary fibrosis; systemic lupus erythematosus (SLE) vasculitis. In addition, polyploids (eg, for seedless fruits) can also be obtained using colchicine III. Colchicine is an indispensable reagent in chromosome research. The colchicine tablet is an anti-gout drug and an anti-tumor drug.

Study on Analytical Method of Colchicine